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Type: Artigo
Title: Vegf Gene Polymorphisms And Outcome Of Epithelial Ovarian Cancer Patients
Author: Camerin
Gabriela Ribeiro; Carvalho Brito
Angelo Borsarelli; Vassallo
Jose; Mauricette Derchain
Sophie Francoise; Passos Lima
Carmen Silvia
Abstract: Since VEGF polymorphisms were associated with variable protein production, we analyzed herein their roles in outcome of epithelial ovarian cancer (EOC) patients. Methods: Genotypes of 85 patients with primary EOC were identified in DNA by real-time PCR. Progression-free survival and overall survival were analyzed using Kaplan-Meier method, univariate Cox model and bootstrap resampling study. Results: At 60 months of follow-up, progression-free survival was shorter in patients with VEGF c.-2578 CC genotype compared with others (52.7 vs 82.2%; p = 0.04). Those patients had 2.15 more chance of presenting disease progression than others (p = 0.04); bootstrap study validated the result (p = 0.03). Conclusion: Our data suggest that VEGF c.-2578C>A polymorphism acts as a prognostic factor in EOC.
Subject: Epithelial Ovarian Cancer
Genetic Polymorphism
Editor: Future Medicine LTD
Citation: Future Oncology. Future Medicine Ltd, v. 13, p. 409 - 414, 2017.
Rights: fechado
Identifier DOI: 10.2217/fon-2016-0299
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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