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Type: Artigo
Title: Antiproliferative Effect Of Synadenium Grantii Hook F. Stems (euphorbiaceae) And A Rare Phorbol Diterpene Ester
Author: Campos
Adriana; Vendramini-Costa
Debora Barbosa; Longato
Giovanna Barbarini; Zermiani
Tailyn; Tasca Gois Ruiz
Ana Lucia; de Carvalho
Joao Ernesto; Pandiella
Atanasio; Cechinel Filho
Abstract: Synadenium grantii is frequently used for the treatment of various diseases such as allergies, gastric disorders, and especially cancer. The aim of this study was to evaluate the possible antiproliferative potential of the methanol extract, fractions, and pure compounds from the stems of S grantii. Phytochemical analysis was carried out by conventional chromatographic techniques, and the antiproliferative activity was analyzed using the sulforhodamine B assay and an MTT-based assay. Nonpolar fraction and its subfractions from the stems of S grantii exhibited promising cytostatic effect against several human tumor cell lines (glioma, breast, kidney, and lung), with total grown inhibition values ranging from 0.37 to 2.9 g/mL. One of the active principles of this plant was identified as a rare phorbol diterpene ester, denoted as 3,4,12,13-tetraacetylphorbol-20-phenylacetate. This compound demonstrated antiproliferative activity against glioma, kidney, lung, and triple-negative breast cancer cell lines. These results demonstrate that S grantii stems produce active principles with relevant antiproliferative potential.
Subject: Synadenium Grantii
Antiproliferative Action
Nonpolar Fraction
Phorbol Ester
Editor: Sage Publications Inc
Thousand Oaks
Citation: International Journal Of Toxicology. Sage Publications Inc, v. 35, p. 666 - 671, 2016.
Rights: fechado
Identifier DOI: 10.1177/1091581816659660
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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