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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailappenzellersimone@yahoo.compt_BR
dc.typeArtigopt_BR
dc.titleAbnormality In Hippocampal Signal Intensity Predicts Atrophy In Patients With Systemic Lupus Erythematosusen
dc.contributor.authorLapapt_BR
dc.contributor.authorA. T.; Pedropt_BR
dc.contributor.authorT.; Francischinellipt_BR
dc.contributor.authorJ.; Coanpt_BR
dc.contributor.authorA. C.; Lavras Costallatpt_BR
dc.contributor.authorL. T.; Cendespt_BR
dc.contributor.authorF.; Appenzellerpt_BR
dc.contributor.authorS.pt_BR
unicamp.author[Lapa, A. T.] Univ Estadual Campinas, Fac Med Sci, Program Child & Adolescent Hlth, Campinas, SP, Brazilpt_BR
unicamp.authorCendes, F.] Univ Estadual Campinas, Fac Med Sci, Dept Neurol, Campinas, SP, Brazilpt_BR
unicamp.authorAppenzeller, S.] Univ Estadual Campinas, Fac Med Sci, Dept Med, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.author.external[Pedro, T.pt_BR
unicamp.author.externalFrancischinelli, J.pt_BR
unicamp.author.externalCoan, A. C.pt_BR
unicamp.author.external[Lavras Costallat, L. T.pt_BR
dc.subjectHippocampal Signal Abnormalityen
dc.subjectGliosisen
dc.subjectCognitive Impairmenten
dc.description.abstractTo quantify signal abnormalities in the hippocampus (Hsig) of patients with systemic lupus erythematosus (SLE) and to determine if Hsig predict hippocampal atrophy (HA) in SLE. Methods We included all SLE patients and healthy age- and sex-matched individuals with two magnetic resonance imaging (MRI) scans performed with a minimum of 1 year interval. All individuals underwent a standardized neuropsychological evaluation. Individual results were converted into standard scores and compared to normative data. SLE patients were additionally assessed for disease activity (SLE Disease Activity Index (SLEDAI)), damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)), and the presence of antiphospholipid antibodies. MRI was performed on an Elscint 2 T scanner and T1 inversion recovery and T2 coronal images were used for analysis. Volumetric (HV) and signal quantification (Hsig) were determined by standardized protocols. Results We included 54 SLE patients (48 women; mean age 32.210.56 years). Hsig were found at study entry in 15 (45.5%) patients. Hsig in the body and tail of non-atrophic hippocampi correlated with progression of volume loss during the follow-up period (r=0.8, p<0.001). The presence of Hsig in the head of atrophic hippocampi correlated with progression of HA (r=0.73, p=0.005) during the same period. No correlation of Hsig and disease activity or prednisone dose was observed. Conclusion HA is frequently observed in SLE patients and volume loss is progressive in a subgroup of patients. The evaluation of Hsig is an easy tool to determine patients that may have progressive hippocampal volume loss and should be followed more closely with MRI and cognitive evaluation.en
dc.relation.ispartofLupuspt_BR
dc.publisherSage Publications LTDpt_BR
dc.publisherLondonpt_BR
dc.date.issued2017pt_BR
dc.date.monthofcirculationmaiopt_BR
dc.identifier.citationLupus. Sage Publications Ltd, v. 26, p. 633 - 639, 2017.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume26pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage633pt_BR
dc.description.lastpage639pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0961-2033pt_BR
dc.identifier.eissn1477-0962pt_BR
dc.identifier.wosidWOS:000399305000009pt_BR
dc.identifier.doi10.1177/0961203316673151pt_BR
dc.identifier.urlhttp://journals.sagepub.com/doi/abs/10.1177/0961203316673151pt_BR
dc.description.sponsorshipFundacao Amparo A Pesquisa Estado Sao Paulo-Brasil [FAPESP 2008/02917-0, 2009/06049-6, 2009/11076-2, 2013/07559-3]pt_BR
dc.description.sponsorshipConselho Nacional Pesquisa Desenvolvimento-Brasil CNPq [300447/2009-4, 471343/2011-0, 302205/2012-8, 473328/2013-5, 157534/2015-4]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2017-11-13T13:12:40Z-
dc.date.accessioned2017-11-13T13:12:40Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:12:40Z (GMT). No. of bitstreams: 1 000399305000009.pdf: 162977 bytes, checksum: c0c4c3c0e62bc1a90f4f44e9d68b5280 (MD5) Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326925-
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