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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAntifungal activity of the ethanolic extracts of Punica granatum L. and evaluation of the morphological and structural modifications of its compounds upon the cells of Candida spp.pt_BR
dc.contributor.authorAnibal, Paula Cristinapt_BR
dc.contributor.authorPeixoto, Iza Teixeira Alvespt_BR
dc.contributor.authorFoglio, Mary Annpt_BR
dc.contributor.authorHöfling, José Franciscopt_BR
unicamp.authorAnibal, Paula Cristina Universidade Estatual de Campinas Estadual de Campinas Faculdade de Odontologia de Piracicaba Disciplina de Microbiologia e Imunologiapt_BR
unicamp.authorPeixoto, Iza Teixeira Alves Universidade Estatual de Campinas Estadual de Campinas Faculdade de Odontologia de Piracicaba Disciplina de Microbiologia e Imunologiapt_BR
unicamp.authorFoglio, Mary Ann Universidade Estatual de Campinas Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas Divisão de Fitoquímicapt_BR
unicamp.authorHöfling, José Francisco Universidade Estatual de Campinas Estadual de Campinas Faculdade de Odontologia de Piracicaba Disciplina de Microbiologia e Imunologiapt_BR
dc.subjectPunica granatumpt_BR
dc.subjectpunicalaginpt_BR
dc.subjectantifungal activitypt_BR
dc.subjectCandida spp.pt_BR
dc.subjectelectron microscopypt_BR
dc.description.abstractEthanolic crude extracts prepared from the arils and seeds, pericarp, peels and from the whole fruit of Punica granatum, known as pomegranate, had their antifungal activity tested against Candida spp. The ethanolic crude extracts were analyzed by Mass Spectrometry and yielded many compounds such as punicalagin and galladydilacton. The extracts from the pericarp and peel showed activity against Candida spp., with MICs of 125 µg/mL. The effect of pericarp and peel extracts upon the morphological and structure of C. albicans and C. krusei were examined by scanning and transmission electron microscopy, with the visualization of an irregular membrane and hyphae, formation of vacuoles and thickening of the cell wall. The data obtained revealed potential antimicrobial activity against yeasts cells of the Candida genus, and the bioactive compounds could be responsible for changes in cell morphology and structure. The data obtained open new perspectives for future research in continuation to this study, where information such as determination of the site of action of the compounds could contribute to an alternative therapy against these organisms.en
dc.relation.ispartofBrazilian Journal of Microbiologypt_BR
dc.publisherSociedade Brasileira de Microbiologiapt_BR
dc.date.issued2013-09-01pt_BR
dc.identifier.citationBrazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 44, n. 3, p. 839-848, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.firstpage839pt_BR
dc.description.lastpage848pt_BR
dc.rightsabertopt_BR
dc.sourceSciELOpt_BR
dc.identifier.issn1517-8382pt_BR
dc.identifier.idScieloS1517-83822013000300027pt_BR
dc.identifier.doi10.1590/S1517-83822013005000060pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1590/S1517-83822013005000060pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000300027pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-07-17T17:59:47Z
dc.date.available2015-11-25T20:07:31Z-
dc.date.accessioned2014-07-17T17:59:47Z
dc.date.accessioned2015-11-25T20:07:31Z-
dc.description.provenanceMade available in DSpace on 2014-07-17T17:59:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-09-01en
dc.description.provenanceMade available in DSpace on 2015-11-25T20:07:31Z (GMT). No. of bitstreams: 2 S1517-83822013000300027.pdf: 4649988 bytes, checksum: 86762f93af41a6054c0be14110a7509c (MD5) S1517-83822013000300027.pdf.txt: 30305 bytes, checksum: 6b08ee2e4ce1935c2531b6b46b42f92c (MD5) Previous issue date: 2013-09-01en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/27571
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/27571-
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