Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243988
Type: Artigo de periódico
Title: Association Between Genetic Polymorphisms In Dna Mismatch Repair-related Genes With Risk And Prognosis Of Head And Neck Squamous Cell Carcinoma
Author: Silva Nogueira
Guilherme Augusto; Lourenco
Gustavo Jacob; Martins Oliveira
Camila Borges; Lima Marson
Fernando Augusto; Lopes-Aguiar
Leisa; Dias Costa
Ericka Francislaine; Penna Lima
Tathiane Regine; Liutti
Vitor Teixeira; Leal
Frederico; Antunes Santos
Vivian Castro; Rinck-Junior
Jose Augusto; Passos Lima
Carmen Silvia
Abstract: We examined the influence of MLH1 c.-93G>A, MSH2 c.211 + 9C>G, MSH3 c.3133G>A and EXO1 c.1765G>A polymorphisms, involved in DNA mismatch repair (MMR), on head and neck (HN) squamous cell carcinoma (SCC) risk and prognosis. Aiming to identify genotypes, DNA from 450 HNSCC patients and 450 controls was analyzed by PCR-RFLP or real time PCR. MSH2 GG plus MSH3 GG (31.7% vs. 18.7%, p = 0.003) genotypes were higher in laryngeal SCC (LSCC) patients than in controls. Carriers of the respective combined genotype were under a 3.69 (95% CI: 1.54-8.81)-fold increased risk of LSCC. Interactions of tobacco and tobacco plus all the above-mentioned polymorphisms on HNSCC and LSCC risk were also evident in study (p = 0.001). At 60 months of follow-up, relapse-free survival (RFS) was shorter in patients with EXO1 GG genotype (54.8% vs. 61.1%, p = 0.03) and overall survival (OS) was shorter in patients with MSH3 GG genotype (42.8% vs. 52.5%, p = 0.02) compared to those with other genotypes, respectively. After multivariate Cox analysis, patients with EXO1 GG and MSH3 GG genotypes had worst RFS (HR: 1.50, 95% CI: 1.03-2.20, p = 0.03) and OS (HR: 1.59, 95% CI: 1.19-2.13, P = 0.002) than those with the remaining genotypes, respectively. Our data present, for the first time, evidence that inherited MLH1 c.-93G>A, MSH2 c.211 + 9C>G, MSH3 c.3133G>A, and EXO1 c.1765G>A abnormalities of DNA MMR pathway are important determinants of HNSCC, particularly among smokers, and predictors of patient outcomes.
Subject: Multifactor Dimensionality Reduction
Primary Lung-cancer
Colorectal-cancer
Susceptibility
Chemotherapy
Population
Tobacco
Methotrexate
Expression
Promoter
Country: HOBOKEN
Editor: WILEY-BLACKWELL
Citation: Association Between Genetic Polymorphisms In Dna Mismatch Repair-related Genes With Risk And Prognosis Of Head And Neck Squamous Cell Carcinoma. Wiley-blackwell, v. 137, p. 810-818 AUG-2015.
Rights: fechado
Identifier DOI: 10.1002/ijc.29435
Address: http://onlinelibrary.wiley.com/doi/10.1002/ijc.29435/abstract;jsessionid=7F7C8AE37030658DAEEEEBEDE97CD3B8.f03t03
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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