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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAlexandre, Eduardo Costapt_BR
dc.contributor.authorunicampCalmasini, Fabiano Beraldipt_BR
dc.contributor.authorunicampCalixto, Marina Ciarallopt_BR
dc.contributor.authorunicampAntunes Edsonpt_BR
dc.typeArtigopt_BR
dc.titleTreatment with metformin improves erectile dysfunction in a murine model of obesity associated with insulin resistancept_BR
dc.contributor.authorSilva, Fabio H.pt_BR
dc.contributor.authorAlexandre, Eduardo C.pt_BR
dc.contributor.authorCalmasini, Fabiano B.pt_BR
dc.contributor.authorCalixto, Marina C.pt_BR
dc.contributor.authorAntunes, Edsonpt_BR
dc.subjectSíndrome metabólicapt_BR
dc.subject.otherlanguageMetabolic syndromept_BR
dc.description.abstractTo evaluate the effects of treatment with metformin on a murine model of obesity-associated erectile dysfunction. MATERIAL AND METHODS C57BL/6 male mice were fed for 10 weeks with standard chow or high-fat diet. Lean and obese mice were treated with the insulin sensitizer metformin (300 mg/kg/day, 2 weeks). Intracavernosal pressure (ICP) and in vitro corpus cavernosum (CC) relaxations to both acetylcholine and electrical field stimulation, as well as phenylephrine-induced contractions, were obtained. Levels of cyclic guanosine monophosphate in CC were detected by enzyme immunoassay. RESULTS High-fat-fed mice exhibited higher body weight and insulin resistance. Cavernous nerve stimulation caused frequency-dependent ICP increases, which were significantly lower in obese compared with lean mice (P < .05). Two-week therapy with metformin reversed the decreased ICP in obese group. The maximal response to acetylcholine in CC was 35% lower (P <. 05) in the obese compared to the lean group, which were restored by metformin treatment. Likewise, the impaired electrical field stimulation-induced CC relaxations in obese mice were also partly restored by metformin. Contractile responses to phenylephrine were significantly greater (P <. 05) in obese compared to lean mice, which were fully restored by metformin. Basal and stimulated cyclic guanosine monophosphate productions in the erectile tissues were significantly lower (P <. 05) in the obese group, an effect fully restored by metformin. CONCLUSION Treatment with metformin restored the erectile function in obese mice, through improvement of in vitro endothelial and nitrergic cavernosal relaxations. Therefore, use of metformin may be a good pharmacologic approach to treat insulin resistance-associated erectile dysfunctionpt
dc.relation.ispartofUrologypt_BR
dc.relation.ispartofabbreviationUrologypt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015pt_BR
dc.date.monthofcirculationAug.pt_BR
dc.identifier.citationTreatment With Metformin Improves Erectile Dysfunction In A Murine Model Of Obesity Associated With Insulin Resistance. Elsevier Science Inc, v. 86, p. AUG-2015.pt_BR
dc.language.isoengpt_BR
dc.description.volume86pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage423.e1pt_BR
dc.description.lastpage423.e6pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0090-4295pt_BR
dc.identifier.eissn1527-9995pt_BR
dc.identifier.doi10.1016/j.urology.2015.04.035pt_BR
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0090429515004203pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2016-06-07T13:34:40Z-
dc.date.accessioned2016-06-07T13:34:40Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:34:40Z (GMT). No. of bitstreams: 1 wos_000361904800067.pdf: 640405 bytes, checksum: 5bec10509be5a87a7f3c4b2c8598d1d7 (MD5) Previous issue date: 2015 Bitstreams deleted on 2020-05-18T20:41:36Z: wos_000361904800067.pdf,. Added 1 bitstream(s) on 2020-05-19T14:31:40Z : No. of bitstreams: 1 000361904800067.pdf: 764658 bytes, checksum: 5b29be11178adf74c434015e51cae908 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243960-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000361904800067-
dc.creator.orcid0000-0002-9482-6799pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.type.formArtigo originalpt_BR
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