Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243274
Type: Artigo de periódico
Title: Association Of Cyp1a1 A4889g And T6235c Polymorphisms With The Risk Of Sporadic Breast Cancer In Brazilian Women
Author: Martins de Oliveira
Camila Borges; Cardoso-Filho
Cassio; Bossi
Leonardo Silveira; Lourenco
Gustavo Jacob; Costa-Gurgel
Maria Salete; Passos Lima
Carmen Silvia
Abstract: OBJECTIVES: We examined the influence of CYP1A1 A4889G and T6235C polymorphisms on the risk of sporadic breast cancer. METHODS: DNA from 742 sporadic breast cancer patients and 742 controls was analyzed using the polymerase chain reaction, followed by the restriction fragment length polymorphism technique. RESULTS: More patients had the CYP1A1 4889AG + GG genotype compared to controls (29.0% versus 23.2%, p=0.004). The G allele carriers had a 1.50-fold increased risk (95% CI: 1.14-1.97) of sporadic breast cancer compared to the other study participants. The frequency of the 4889AG + GG genotype among the Caucasian patients was higher than in the non-Caucasian patients (30.4% versus 20.2%, p=0.03) and controls (30.4% versus 23.2%, p=0.002). Caucasians and G allele carriers had a 1.61-fold increased risk (95% CI: 1.20-2.15) of sporadic breast cancer compared to other subjects. The CYP1A1 4889AG + GG genotype was more common among patients with a younger median age at first full-term pregnancy than among controls (33.8% versus 23.2%, p=0.001) and subjects whose first full-term pregnancies occurred at an older age (33.8% versus 26.1%, p=0.03). Women with the CYP1A1 4889AG + GG genotype and earlier first full-term pregnancies had a 1.87-fold (95% CI: 1.32-2.67) increased risk of sporadic breast cancer compared to the other study participants. Excess CYP1A1 4889AG + GG (39.8% versus 27.1%, p=0.01) and 6235TC + CC (48.4% versus 35.9%, p=0.02) genotypes were also observed in patients with grade I and II tumors compared to patients with grade III tumors and controls (39.8% versus 23.2%, p=0.04; 48.4% versus 38.6%, p=0.04). The G and C allele carriers had a 2.44-fold (95% CI: 1.48-4.02) and 1.67-fold (95% CI: 1.03-2.69) increased risk, respectively, of developing grade I and II tumors compared to other subjects. CONCLUSIONS: The CYP1A1 A4889G and T6235C polymorphisms may alter the risk of sporadic breast cancer in Brazilian women.
Subject: Susceptibility Gene Polymorphisms
Estrogen-metabolizing Enzymes
North Indian Women
Term Follow-up
Cytochrome P4501a1
Gstt1 Polymorphisms
Cigarette-smoking
African-american
Chinese Women
White Women
Country: SAO PAULO
Editor: HOSPITAL CLINICAS, UNIV SAO PAULO
Citation: Association Of Cyp1a1 A4889g And T6235c Polymorphisms With The Risk Of Sporadic Breast Cancer In Brazilian Women. Hospital Clinicas, Univ Sao Paulo, v. 70, p. 680-685 2015.
Rights: fechado
Identifier DOI: 10.6061/clinics/2015(10)04
Address: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1807-59322015001000680&lng=en&nrm=iso
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
wos_000364422500004.pdf213.77 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.