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Type: Artigo de periódico
Title: Vascular Endothelial Growth Factor (vegf) Polymorphism And Increased Risk Of Epithelial Ovarian Cancer
Author: Rinck-Junior
Jose Augusto; Oliveira
Cristiane; lourenco
Gustavo Jacob; Martinho Sagarra
Regina Aparecida; Mauricette Derchain
Sophie Francoise; Segalla
Jose Getulio; Passos Lima
Carmen Silvia
Abstract: Angiogenesis (AG) is essential for epithelial ovarian cancer (EOC) development. Vascular endothelial growth factor (VEGF), encoded by the VEGF gene, and endostatin, the product of the COL18A1 gene, act as a potent promoter and an inhibitor of AG, respectively. In the present study, we tested whether VEGF C936T and COL18A1 D104N polymorphisms alter the risk of EOC. Genomic DNA from 131 EOC patients and 137 controls were analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. The differences between groups were analyzed by chi (2) or Fisher's exact test and logistic regression analysis. The frequency of the VEGF 936CC genotype was higher in patients than in controls (84.8 % vs. 75.3 %, P = 0.03). Individuals with respective genotypes had a 1.98 (95 % CI 1.04-3.78)-fold increased risk of EOC than those with the remaining genotypes. An excess of VEGF 936CC plus COL18A1 DN genotype was seen in patients when compared to controls (48.6 % vs. 30.5 %); however, only a tendency toward a statistically significant difference in genotype frequencies was found in the study (P = 0.06), reflecting a trend toward an increased risk of 2.44 for EOC in carriers of the combined genotype. Our data present, for the first time, preliminary evidence that VEGF C936T alone or combined with the COL18A1 D104N polymorphism of AG constitutes an important inherited EOC determinant.
Subject: Sporadic Breast-cancer
Factor Gene
936 C/t
Country: NEW YORK
Citation: Vascular Endothelial Growth Factor (vegf) Polymorphism And Increased Risk Of Epithelial Ovarian Cancer. Springer, v. 141, p. 69-73 JAN-2015.
Rights: fechado
Identifier DOI: 10.1007/s00432-014-1786-0
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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