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Type: Artigo de periódico
Title: Non-motor Symptoms In Patients With Hereditary Spastic Paraplegia Caused By Spg4 Mutations.
Author: Servelhere, K R
Faber, I
Saute, J A M
Moscovich, M
D'Abreu, A
Jardim, L B
Teive, H A G
Lopes-Cendes, I
Franca, M C
Abstract: Non-motor manifestations are frequently overlooked in degenerative disorders and little is known about their frequency and clinical relevance in SPG4 hereditary spastic paraplegia (SPG4-HSP). Thirty patients with SPG4-HSP and 30 healthy controls answered the Modified Fatigue Impact Scale, Epworth Sleepiness Scale, Brief Pain Inventory and Beck Depression Inventory. Student's t test was used to compare groups and linear regression was used to assess correlations. Patients had higher fatigue scores than controls (31.0 ± 16.5 vs. 14.5 ± 16.0, P = 0.002) as well as pain (3.4 ± 2.7 vs. 1.0 ± 1.6, P = 0.001) and depression (12.7 ± 8.9 vs. 4.4 ± 3.8, P < 0.001, respectively). Fatigue was associated with depression and possibly with disease severity (P = 0.008 and 0.07, respectively). Fatigue, pain and depression are frequent and often severe manifestations in patients with SPG4-HSP.
Subject: Spg4
Non-motor Symptoms
Spastic Paraplegia
Citation: European Journal Of Neurology. v. 23, n. 2, p. 408-411, 2016-Feb.
Rights: embargo
Identifier DOI: 10.1111/ene.12839
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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