Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/235230
Type: Artigo de periódico
Title: Chemical Composition Of The Essential Oil From The Leaves Of Anaxagorea Brevipes (annonaceae) And Evaluation Of Its Bioactivity.
Author: de Alencar, Danielle Cardoso
Pinheiro, Maria Lúcia Belém
Pereira, José Lamak da Silva
de Carvalho, João Ernesto
Campos, Francinete Ramos
Serain, Alessandra Freitas
Tirico, Ricardo Brunelli
Hernández-Tasco, Alvaro José
Costa, Emmanoel Vilaça
Salvador, Marcos José
Abstract: The essential oil obtained by hydrodistillation from leaves of Anaxagorea brevipes was analysed by gas chromatography fitted with a flame ionisation detector (GC-FID) and coupled to mass spectrometry (GC-MS). Thirty one components were identified, representing around 75.7% of total oil. The major components were β-eudesmol (13.16%), α-eudesmol (13.05%), γ-eudesmol (7.54%), guaiol (5.12%), caryophyllene oxide (4.18%) and β-bisabolene (4.10%). The essential oil showed antimicrobial activity against Gram-positive bacteria and yeast with the MIC values between 25.0 and 100 μg/mL. The highest antiproliferative activity was observed for the oil against MCF-7 (breast, TGI = 12.8 μg/mL), NCI-H460 (lung, TGI = 13.0 μg/mL) and PC-3 (prostate, TGI = 9.6 μg/mL) cell lines, while against no cancer cell line HaCat (keratinocyte) the TGI was 38.8 μg/mL. The oil exhibited a small antioxidant activity assessed through ORAC-FL assay (517 μmol TE/g). This is the first report regarding the chemical composition and bioactivity of A. brevipes essential oil.
Subject: Anaxagorea Brevipes
Annonaceae
Bioactivity
Essential Oil
Citation: Natural Product Research. v. 30, n. 9, p. 1-5, 2015-Nov.
Rights: embargo
Identifier DOI: 10.1080/14786419.2015.1101103
Address: http://www.tandfonline.com/doi/pdf/10.1080/14786419.2015.1101103
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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