Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/2150
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleMRI-Texture Analysis of Corpus Callosum, Thalamus, Putamen, and Caudate in Machado-Joseph Diseasept_BR
dc.contributor.authorde Oliveira, Marcia S.pt_BR
dc.contributor.authorD'Abreu, Anelyssapt_BR
dc.contributor.authorFranca, Marcondes C., Jr.pt_BR
dc.contributor.authorLopes-Cendes, Isciapt_BR
dc.contributor.authorCendes, Fernandopt_BR
dc.contributor.authorCastellano, Gabrielapt_BR
unicamp.authorD'Abreu, Anelyssapt_BR
unicamp.authorFranca, Marcondes C., Jr.pt_BR
unicamp.authorLopes-Cendes, Isciapt_BR
unicamp.authorCendes, Fernandopt_BR
unicamp.author.externalde Oliveira, Marcia S.pt
unicamp.author.externalCastellano, Gabrielapt
dc.subjectMachado-Joseph diseasept_BR
dc.subjecttexture analysispt_BR
dc.subjectMRIpt_BR
dc.subjectmovement disorderspt_BR
dc.subjectataxypt_BR
dc.subject.wosSPINOCEREBELLAR ATAXIA TYPE-3pt_BR
dc.subject.wosPOSITRON-EMISSION-TOMOGRAPHYpt_BR
dc.subject.wosFOCAL CORTICAL DYSPLASIApt_BR
dc.subject.wosCOMPUTED-TOMOGRAPHYpt_BR
dc.subject.wosMULTIPLE-SCLEROSISpt_BR
dc.subject.wosWHITE-MATTERpt_BR
dc.subject.wosBRAINpt_BR
dc.subject.wosIMAGESpt_BR
dc.subject.wosDISCRIMINATIONpt_BR
dc.subject.wosACCURACYpt_BR
dc.description.abstractBACKGROUND/PURPOSE Texture analysis (TA) is a branch of image processing, which attempts to convey "texture" information from digital images, such as magnetic resonance images (MRI). Machado-Joseph disease (MJD) affects mainly cerebellum and brainstem, but recent studies have shown that other cerebral structures may also be affected. OBJECTIVE To investigate subtle structural abnormalities in corpus callosum (CC), thalami, putamen, and caudate nuclei of patients with MJD using TA. METHODS Eighteen healthy volunteers and 18 patients with MJD were studied (mean age at disease onset = 34.7 years; disease duration = 9.6 years; mean expanded CAG in the MJD1 gene = 73). A TA approach based on the gray-level cooccurrence matrix was applied to T1-MRI. Regions of interest were manually segmented for each subject, and texture parameters were computed for each of the aforementioned anatomical structures. RESULTS TA parameters showed differences between the 2 groups for the caudate nuclei, thalami, and putamen. No differences were found for the CC. CONCLUSIONS TA was capable of detecting tissue alterations in MRI of patients with MJD. These alterations were in areas already shown to be affected by histopathological studies. In addition, we confirmed the thalamic involvement in patients with MJD, which had only been demonstrated in volumetric studies.pt
dc.relation.ispartofJournal of Neuroimagingpt_BR
dc.publisher.cityMaldenpt_BR
dc.publisherWiley-Blackwellpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationJournal of Neuroimaging. Wiley-Blackwell, v.22, n.1, p.46-52, 2012pt_BR
dc.language.isoengpt_BR
dc.description.volume22pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage46pt_BR
dc.description.lastpage52pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1051-2284pt_BR
dc.identifier.wosidWOS:000299158500009pt_BR
dc.identifier.doi10.1111/j.1552-6569.2010.00553.xpt_BR
dc.date.available2013-09-19T18:06:26Z
dc.date.available2016-07-01T15:45:01Z-
dc.date.accessioned2013-09-19T18:06:26Z
dc.date.accessioned2016-07-01T15:45:01Z-
dc.description.provenanceMade available in DSpace on 2013-09-19T18:06:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2016-07-01T15:45:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2150
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2150-
dc.contributor.departmentNeurologia
dc.contributor.unidadeFCMpt
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.