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Type: Artigo de periódico
Title: Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae)
Author: Silva, Dayanne Meneses
Costa, Emmanoel Vilaça
Nogueira, Paulo Cesar de Lima
Moraes, Valéria Regina de Souza
Cavalcanti, Sócrates Cabral de Holanda
Salvador, Marcos José
Ribeiro, Luis Henrique Gonzaga
Gadelha, Fernanda Ramos
Barison, Andersson
Ferreira, Antonio Gilberto
Abstract: Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1.
Subject: Xylopia laevigata
larvicidal and antifungal properties
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 35, n. 8, p. 1570-1576, 2012.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422012000800015
Date Issue: 1-Jan-2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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