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Type: Artigo de periódico
Title: Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: principais métodos analíticos para sua determinação
Title Alternative: Reactive oxygen and nitrogen species, antioxidants and markers of oxidative damage in human blood: main analytical methods for their determination
Author: Vasconcelos, Sandra Mary Lima
Goulart, Marília Oliveira Fonseca
Moura, José Benedito de França
Manfredini, Vanusa
Benfato, Mara da Silveira
Kubota, Lauro Tatsuo
Abstract: We review here the chemistry of reactive oxygen and nitrogen species, their biological sources and targets; particularly, biomolecules implicated in the redox balance of the human blood, and appraise the analytical methods available for their detection and quantification. Those biomolecules are represented by the enzymatic antioxidant defense machinery, whereas coadjutant reducing protection is provided by several low molecular weight molecules. Biomolecules can be injured by RONS yielding a large repertoire of oxidized products, some of which can be taken as biomarkers of oxidative damage. Their reliable determination is of utmost interest for their potentiality in diagnosis, prevention and treatment of maladies.
Subject: biomarkers of oxidative stress
oxidative and nitrosative stress
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 30, n. 5, p. 1323-1338, 2007.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422007000500046
Date Issue: 1-Oct-2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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