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Type: Artigo de periódico
Title: Whole Cortical And Default Mode Network Mean Functional Connectivity As Potential Biomarkers For Mild Alzheimer's Disease.
Author: Balthazar, Marcio Luiz Figueredo
de Campos, Brunno Machado
Franco, Alexandre Rosa
Damasceno, Benito Pereira
Cendes, Fernando
Abstract: The search for an Alzheimer's disease (AD) biomarker is one of the most relevant contemporary research topics due to the high prevalence and social costs of the disease. Functional connectivity (FC) of the default mode network (DMN) is a plausible candidate for such a biomarker. We evaluated 22 patients with mild AD and 26 age- and gender-matched healthy controls. All subjects underwent resting functional magnetic resonance imaging (fMRI) in a 3.0 T scanner. To identify the DMN, seed-based FC of the posterior cingulate was calculated. We also measured the sensitivity/specificity of the method, and verified a correlation with cognitive performance. We found a significant difference between patients with mild AD and controls in average z-scores: DMN, whole cortical positive (WCP) and absolute values. DMN individual values showed a sensitivity of 77.3% and specificity of 70%. DMN and WCP values were correlated to global cognition and episodic memory performance. We showed that individual measures of DMN connectivity could be considered a promising method to differentiate AD, even at an early phase, from normal aging. Further studies with larger numbers of participants, as well as validation of normal values, are needed for more definitive conclusions.
Subject: Aged
Alzheimer Disease
Biological Markers
Brain Mapping
Case-control Studies
Cognition Disorders
Image Processing, Computer-assisted
Magnetic Resonance Imaging
Memory, Episodic
Middle Aged
Sensitivity And Specificity
Severity Of Illness Index
Default Mode Network
Resting State Fmri
Citation: Psychiatry Research. v. 221, n. 1, p. 37-42, 2014-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.pscychresns.2013.10.010
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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