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Type: Artigo de periódico
Title: Performance Of Phalangeal Quantitative Ultrasound Parameters In The Evaluation Of Reduced Bone Mineral Density Assessed By Dx In Patients With 21 Hydroxylase Deficiency.
Author: Gonçalves, Ezequiel M
Sewaybricker, Leticia E
Baptista, Fatima
Silva, Analiza M
Carvalho, Wellington R G
Santos, Allan O
de Mello, Maricilda P
Lemos-Marini, Sofia H V
Guerra, Gil
Abstract: The purpose of this study was to verify the performance of quantitative ultrasound (QUS) parameters of proximal phalanges in the evaluation of reduced bone mineral density (BMD) in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21 OHD). Seventy patients with 21 OHD (41 females and 29 males), aged between 6-27 y were assessed. The QUS measurements, amplitude-dependent speed of sound (AD-SoS), bone transmission time (BTT), and ultrasound bone profile index (UBPI) were obtained using the BMD Sonic device (IGEA, Carpi, Italy) on the last four proximal phalanges in the non-dominant hand. BMD was determined by dual energy X-ray (DXA) across the total body and lumbar spine (LS). Total body and LS BMD were positively correlated to UBPI, BTT and AD-SoS (correlation coefficients ranged from 0.59-0.72, p < 0.001). In contrast, when comparing patients with normal and low (Z-score < -2) BMD, no differences were found in the QUS parameters. Furthermore, UBPI, BTT and AD-SoS measurements were not effective for diagnosing patients with reduced BMD by receiver operator characteristic curve parameters. Although the AD-SoS, BTT and UBPI showed significant correlations with the data obtained by DXA, they were not effective for diagnosing reduced bone mass in patients with 21 OHD.
Subject: Absorptiometry, Photon
Adrenal Hyperplasia, Congenital
Bone Density
Elasticity Imaging Techniques
Finger Phalanges
Image Interpretation, Computer-assisted
Reproducibility Of Results
Sensitivity And Specificity
Young Adult
Bone Mass
Congenital Adrenal Hyperplasia
Citation: Ultrasound In Medicine & Biology. v. 40, n. 7, p. 1414-9, 2014-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.ultrasmedbio.2013.12.027
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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