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Type: Artigo de periódico
Title: Diagnosis Of Scott Syndrome In Patient With Bleeding Disorder Of Unknown Cause.
Author: Flores-Nascimento, Mariane C
Orsi, Fernanda L A
Yokoyama, Ana P
Pereira, Fernanda G
Lorand-Metze, Irene
De Paula, Erich V
Castro, Vagner
Annichino-Bizzacchi, Joyce M
Abstract: Scott syndrome is a rare bleeding disorder due to an impaired exposure of phosphatidilserine on the platelet membrane, compromising the platelet procoagulant activity, thrombin generation and, thus, the clot formation. We report a case of a 17-year-old female adolescent with bleeding episodes of unknown cause. She had normal coagulation, but altered platelet aggregation under arteriolar flow, indicating platelet dysfunction. Furthermore, the expression of Annexin V was markedly reduced and the diagnosis of Scott syndrome was established. She was treated with platelet transfusions and demonstrated a clinical improvement. Scott syndrome may be investigated in cases with bleeding history and normal coagulation tests.
Subject: Adolescent
Blood Coagulation Disorders
Blood Coagulation Tests
Blood Platelets
Citation: Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis. v. 23, n. 1, p. 75-7, 2012-Jan.
Rights: fechado
Identifier DOI: 10.1097/MBC.0b013e32834d0c81
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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