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Type: Artigo de periódico
Title: Downregulation Of Irs2 In Myelodysplastic Syndrome: A Possible Role In Impaired Hematopoietic Cell Differentiation.
Author: Machado-Neto, João Agostinho
Favaro, Patricia
Lazarini, Mariana
da Silva Santos Duarte, Adriana
Archangelo, Leticia Fröhlich
Lorand-Metze, Irene
Costa, Fernando Ferreira
Saad, Sara Teresinha Olalla
Traina, Fabiola
Abstract: Insulin receptor substrate 2 (IRS2) is an adaptor protein that associates with the receptor of erythropoietin, insulin-like growth factor 1 and thrombopoietin; however, its role is not known in myelodysplasia. We, herein, report a significantly lower IRS2 expression in MDS cells, compared to normal cells. IRS2 expression was reduced in high-risk, compared to low-risk disease, and positively correlated with neutrophil and platelet counts. IRS2 was upregulated during erythroid differentiation of CD34(+) cells from normal donors and low-risk MDS patients and also during erythroid, granulocytic and megakaryocytic differentiation in cell lines. These results suggest that defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in MDS.
Subject: Adult
Aged, 80 And Over
Case-control Studies
Cell Differentiation
Cell Line, Tumor
Cell Transformation, Neoplastic
Gene Expression Regulation, Leukemic
Hematopoietic Stem Cells
Insulin Receptor Substrate Proteins
Middle Aged
Myelodysplastic Syndromes
Risk Factors
Young Adult
Citation: Leukemia Research. v. 36, n. 7, p. 931-5, 2012-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2012.03.002
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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