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dc.typeArtigo de periódicopt_BR
dc.titleMother-to-child Transmission Of Human Immunodeficiency Virus In Aten Years Period.pt_BR
dc.contributor.authorDelicio, Adriane Mpt_BR
dc.contributor.authorMilanez, Helainept_BR
dc.contributor.authorAmaral, Elianapt_BR
dc.contributor.authorMorais, Sirlei Spt_BR
dc.contributor.authorLajos, Giuliane Jpt_BR
dc.contributor.authore Silva, João Luiz C Pintopt_BR
dc.contributor.authorCecatti, José Guilhermept_BR
unicamp.authorAdriane M Delicio, Department of Obstetrics and Gynecology, School of Medicine, University of Campinas, Brazil. adri36_unicamp@hotmail.compt_BR Milanez,pt Amaral,pt S Morais,pt J Lajos,ptão Luiz C Pinto e Silva,pté Guilherme Cecatti,pt
dc.subjectAnti-hiv Agentspt_BR
dc.subjectAntiretroviral Therapy, Highly Activept_BR
dc.subjectBirth Weightpt_BR
dc.subjectCd4 Lymphocyte Countpt_BR
dc.subjectCesarean Sectionpt_BR
dc.subjectHiv Infectionspt_BR
dc.subjectInfant, Newbornpt_BR
dc.subjectInfectious Disease Transmission, Verticalpt_BR
dc.subjectMedication Adherencept_BR
dc.subjectPregnancy Complications, Infectiouspt_BR
dc.subjectPrenatal Carept_BR
dc.subjectRetrospective Studiespt_BR
dc.subjectRisk Factorspt_BR
dc.subjectViral Loadpt_BR
dc.subjectYoung Adultpt_BR
dc.description.abstractto evaluate mother-to-child transmission (MTCT) rates and related factors in HIV-infected pregnant women from a tertiary hospital between 2000 and 2009. cohort of 452 HIV-infected pregnant women and their newborns. Data was collected from recorded files and undiagnosed children were enrolled for investigation. qui-square test, Fisher exact test, Student t test, Mann-Whitney test, ANOVA, risk ratio and confidence intervals. MTCT occurred in 3.74%. The study population displayed a mean age of 27 years; 86.5% were found to have acquired HIV through sexual contact; 55% were aware of the diagnosis prior to the pregnancy; 62% were not using HAART. Mean CD4 cell-count was 474 cells/ml and 70.3% had undetectable viral loads in the third trimester. HAART included nevirapine in 35% of cases and protease inhibitors in 55%; Zidovudine monotherapy was used in 7.3%. Mean gestational age at delivery was 37.2 weeks and in 92% by caesarian section; 97.2% received intravenous zidovudine. Use of AZT to newborn occurred in 100% of them. Factors identified as associated to MTCT were: low CD4 cell counts, elevated viral loads, maternal AIDS, shorter periods receiving HAART, other conditions (anemia, IUGR (intra uterine growth restriction), oligohydramnium), coinfecctions (CMV and toxoplasmosis) and the occurrence of labor. Use of HAART for longer periods, caesarian and oral zidovudine for the newborns were associated with a decreased risk. Poor adhesion to treatment was present in 13 of the 15 cases of transmission; in 7, coinfecctions were diagnosed (CMV and toxoplasmosis). Use of HAART and caesarian delivery are protective factors for mother-to-child transmission of HIV. Maternal coinfecctions and other conditions were risk factors for MTCT.en
dc.relation.ispartofReproductive Healthpt_BR
dc.relation.ispartofabbreviationReprod Healthpt_BR
dc.identifier.citationReproductive Health. v. 8, p. 35, 2011.pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T13:22:03Z (GMT). No. of bitstreams: 1 pmed_22129112.pdf: 240204 bytes, checksum: 6b8380b0ab1404ab8b427eb0259b79c8 (MD5) Previous issue date: 2011en
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