Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198891
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA Novel Association Of Acquired Adamts13 Inhibitor And Acute Dengue Virus Infection.pt_BR
dc.contributor.authorRossi, Fernanda Cpt_BR
dc.contributor.authorAngerami, Rodrigo Npt_BR
dc.contributor.authorde Paula, Erich Vpt_BR
dc.contributor.authorOrsi, Fernanda Lpt_BR
dc.contributor.authorShang, Dezhipt_BR
dc.contributor.authordel Guercio, Vânia Mpt_BR
dc.contributor.authorResende, Mariângela Rpt_BR
dc.contributor.authorAnnichino-Bizzacchi, Joyce Mpt_BR
dc.contributor.authorda Silva, Luiz Jpt_BR
dc.contributor.authorZheng, X Longpt_BR
dc.contributor.authorCastro, Vagnerpt_BR
unicamp.authorFernanda C Rossi, Hematology and Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, Brazil.pt_BR
unicamp.author.externalRodrigo N Angerami,pt
unicamp.author.externalErich V de Paula,pt
unicamp.author.externalFernanda L Orsi,pt
unicamp.author.externalDezhi Shang,pt
unicamp.author.externalVânia M del Guercio,pt
unicamp.author.externalMariângela R Resende,pt
unicamp.author.externalJoyce M Annichino-Bizzacchi,pt
unicamp.author.externalLuiz J da Silva,pt
unicamp.author.externalX Long Zheng,pt
unicamp.author.externalVagner Castro,pt
dc.subjectAdam Proteinspt_BR
dc.subjectAcute Diseasept_BR
dc.subjectAutoantibodiespt_BR
dc.subjectBlood Plateletspt_BR
dc.subjectDenguept_BR
dc.subjectHumanspt_BR
dc.subjectImmunoglobulin Gpt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectPlasma Exchangept_BR
dc.subjectThrombotic Microangiopathiespt_BR
dc.description.abstractDengue is a mosquito-borne viral disease with an increasing incidence worldwide. Thrombocytopenia is a common finding in dengue virus (DV) infection; however, the underlying mechanisms remain unknown. Here we provide the first evidence of a case of antibody formation against ADAMTS13 (ADAMTS13 inhibitor) in the course of a severe acute DV infection resulting in thrombotic microangiopathy (TMA). The patient presented with classical dengue symptoms (positive epidemiology, high fever, myalgia, predominantly in the lower limbs and lumbar region for 1 week) and, after 11 days of initial symptoms, developed TMA. Clinical and laboratorial investigation of dengue and TMA was performed. The patient presented with ADAMTS13 inhibitor (IgG) during the acute phase of the disease, without anti-platelet antibodies detectable. Dengue infection had laboratorial confirmation. There were excellent clinical and laboratory responses to 11 serial plasma exchanges. Anti-ADAMTS13 inhibitor disappeared after remission of TMA and dengue resolution. No recurrence of TMA symptoms was observed after 2-year follow-up. Although the real incidence of dengue-related TMA is unknown, this case provides the basis for future epidemiologic studies on acquired ADAMTS13 deficiency in DV infection. The prompt clinical recognition of this complication and early installment of specific therapy with plasma exchange are likely to improve the outcome of severe cases of dengue.en
dc.relation.ispartofTransfusionpt_BR
dc.relation.ispartofabbreviationTransfusionpt_BR
dc.date.issued2010-Janpt_BR
dc.identifier.citationTransfusion. v. 50, n. 1, p. 208-12, 2010-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume50pt_BR
dc.description.firstpage208-12pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1537-2995pt_BR
dc.identifier.doi10.1111/j.1537-2995.2009.02391.xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19788513pt_BR
dc.date.available2015-11-27T13:17:56Z-
dc.date.accessioned2015-11-27T13:17:56Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:17:56Z (GMT). No. of bitstreams: 1 pmed_19788513.pdf: 164345 bytes, checksum: 68d5bf5e656fe11c0caf133da84ba06f (MD5) Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198891-
dc.identifier.idPubmed19788513pt_BR
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