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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFetal Genotyping For Platelets Antigens: A Precise Tool For Alloimmune Thrombocytopenia: Case Report And Literature Review.pt_BR
dc.contributor.authorNomura, Marcelo Luíspt_BR
dc.contributor.authorCouto, Eglept_BR
dc.contributor.authorMartinelli, Beatriz Moraespt_BR
dc.contributor.authorBarjas-Castro, Maria Lourdespt_BR
dc.contributor.authorBarini, Ricardopt_BR
dc.contributor.authorPassini Júnior, Renatopt_BR
dc.contributor.authorCastro, Vagnerpt_BR
unicamp.authorMarcelo Luís Nomura, Hematology and Hemotherapy Center, Centro de Atenção Integral à Saúde da Mulher (CAISM), Universidade Estadual de Campinas (Unicamp), Cidade Universitária, CEP 13084-881 Campinas, SP, Brazil. mlnomura@unicamp.brpt_BR
unicamp.author.externalEgle Couto,pt
unicamp.author.externalBeatriz Moraes Martinelli,pt
unicamp.author.externalMaria Lourdes Barjas-Castro,pt
unicamp.author.externalRicardo Barini,pt
unicamp.author.externalRenato Passini Júnior,pt
unicamp.author.externalVagner Castro,pt
dc.subjectAntigens, Human Plateletpt_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectImmunoglobulins, Intravenouspt_BR
dc.subjectInfant, Newbornpt_BR
dc.subjectIsoantigenspt_BR
dc.subjectMalept_BR
dc.subjectPrednisonept_BR
dc.subjectPregnancypt_BR
dc.subjectThrombocytopeniapt_BR
dc.subjectUltrasonography, Prenatalpt_BR
dc.description.abstractMaternal-fetal alloimmune thrombocytopenia complicates about 0.1% of all pregnancies and is associated with major fetal and neonatal morbidity and mortality, especially spontaneous central nervous system bleeding leading to death and neurological handicaps. Successful prevention and treatment depend on the identification of at-risk possible carriers of anti-platelet antibodies. We report a case of a mother with a previous child that developed neonatal hemorrhage; HPA-5b anti-platelet antibodies were detected post-natally. During the next pregnancy, fetal genotyping confirmed the presence of HPA-5b antigen; she was treated with weekly intravenous human immunoglobulin and oral prednisone. Pregnancy evolved without remarkable features and a full-term baby was delivered, with normal platelet counts. Fetal alloimmune thrombocytopenia is a potentially lethal condition, but early detection and prevention lead to successful outcome in most cases.en
dc.relation.ispartofArchives Of Gynecology And Obstetricspt_BR
dc.relation.ispartofabbreviationArch. Gynecol. Obstet.pt_BR
dc.date.issued2010-Novpt_BR
dc.identifier.citationArchives Of Gynecology And Obstetrics. v. 282, n. 5, p. 573-5, 2010-Nov.pt_BR
dc.language.isoengpt_BR
dc.description.volume282pt_BR
dc.description.firstpage573-5pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1432-0711pt_BR
dc.identifier.doi10.1007/s00404-010-1415-3pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20217108pt_BR
dc.date.available2015-11-27T13:17:38Z-
dc.date.accessioned2015-11-27T13:17:38Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:17:38Z (GMT). No. of bitstreams: 1 pmed_20217108.pdf: 203539 bytes, checksum: ee7fd835ca7f9102e7258c523bcc4f50 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198750-
dc.identifier.idPubmed20217108pt_BR
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