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Type: Artigo de periódico
Title: Fetal Genotyping For Platelets Antigens: A Precise Tool For Alloimmune Thrombocytopenia: Case Report And Literature Review.
Author: Nomura, Marcelo Luís
Couto, Egle
Martinelli, Beatriz Moraes
Barjas-Castro, Maria Lourdes
Barini, Ricardo
Passini Júnior, Renato
Castro, Vagner
Abstract: Maternal-fetal alloimmune thrombocytopenia complicates about 0.1% of all pregnancies and is associated with major fetal and neonatal morbidity and mortality, especially spontaneous central nervous system bleeding leading to death and neurological handicaps. Successful prevention and treatment depend on the identification of at-risk possible carriers of anti-platelet antibodies. We report a case of a mother with a previous child that developed neonatal hemorrhage; HPA-5b anti-platelet antibodies were detected post-natally. During the next pregnancy, fetal genotyping confirmed the presence of HPA-5b antigen; she was treated with weekly intravenous human immunoglobulin and oral prednisone. Pregnancy evolved without remarkable features and a full-term baby was delivered, with normal platelet counts. Fetal alloimmune thrombocytopenia is a potentially lethal condition, but early detection and prevention lead to successful outcome in most cases.
Subject: Antigens, Human Platelet
Immunoglobulins, Intravenous
Infant, Newborn
Ultrasonography, Prenatal
Citation: Archives Of Gynecology And Obstetrics. v. 282, n. 5, p. 573-5, 2010-Nov.
Rights: fechado
Identifier DOI: 10.1007/s00404-010-1415-3
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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