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Type: Artigo de periódico
Title: Smoking Worsens The Prognosis Of Mild Abnormalities In Cervical Cytology.
Author: Guarisi, Renata
Sarian, Luis Otavio
Hammes, Luciano Serpa
Longatto-Filho, Adhemar
Derchain, Sophie F M
Roteli-Martins, Cecília
Naud, Paulo
Erzen, Mojca
Branca, Margherita
Tatti, Sílvio
Costa, Silvano
Syrjänen, Stina
Bragança, Joana F
Syrjänen, Kari
Abstract: To examine the effect of smoking on the incidence of low- and high-grade cervical intraepithelial neoplasia (CIN) in women with a baseline Pap smear of atypical squamous cells (ASC) or a low-grade squamous intraepithelial lesion (LSIL). Prospective study in which a cohort of women with normal colposcopy and ASC/LSIL at baseline were followed at 6-month intervals of up to 36 months. Women were grouped in post-hoc analysis according to their smoking behavior: never (or past) smokers and current smokers. This report was based on data from the Latin American Screening Study, conducted in Sao Paulo, Campinas, Porto Alegre (Brazil) and Buenos Aires (Argentina). A subset of 150 women derived from a cohort of 1,011 women. Multivariate Cox analysis and Kaplan-Meier curves were used. Low- and high-grade CIN during follow-up. The only factor related to an increased risk of developing CIN was the positive high-risk (hr) HPV status (hazard ratio (HR) = 3.42; 95% CI: 1.11-9.43). A total of 21 cases of incident CIN were detected during follow-up. Of these, 11 appeared in the group of 67 smokers and 10 among the 83 non-smoker women (log-rank, p=0.33). Smoking status was not associated with the risk of developing CIN (HR = 0.73; 95% CI: 0.40-1.33). However, when restricting the analysis to high-grade CIN only (11 cases), the probability of developing the disease was significantly higher among smokers (p=0.04). Smoking contributes additional risk for developing high-grade CIN in women with ASC or LSIL cytology but normal colposcopy.
Subject: Adult
Cervical Intraepithelial Neoplasia
Cervix Uteri
Cohort Studies
Confidence Intervals
Follow-up Studies
Kaplan-meier Estimate
Multivariate Analysis
Odds Ratio
Papanicolaou Test
Papillomavirus Infections
Proportional Hazards Models
Prospective Studies
Risk Factors
Uterine Cervical Neoplasms
Vaginal Smears
Citation: Acta Obstetricia Et Gynecologica Scandinavica. v. 88, n. 5, p. 514-20, 2009.
Rights: fechado
Identifier DOI: 10.1080/00016340902846072
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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