Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198200
Type: Artigo de periódico
Title: Experimental Animal Model And Rna Interference: A Promising Association For Bladder Cancer Research.
Author: Reis, Leonardo Oliveira
Pereira, Tiago Campos
Favaro, Wagner José
Cagnon, Valéria Helena Alves
Lopes-Cendes, Iscia
Ferreira, Ubirajara
Abstract: Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will largely depend on their efficient and safe in vivo delivery and on avoiding accidental off-target effects. Intravesical siRNA is a strategy which may be the best deliver option to surperficial BC like intravesical immunotherapy. Its direct action might allow a continuous intracellular exposure to effective siRNA concentrations. While the procedure of transurethral siRNA administration is promising for BC research allowing detection of new targets in BC therapy, the optimal intravesical carrier and the best target(s) to siRNA are to be determined.
Subject: Animals
Biomedical Research
Disease Models, Animal
Rna Interference
Urinary Bladder Neoplasms
Citation: World Journal Of Urology. v. 27, n. 3, p. 353-61, 2009-Jun.
Rights: fechado
Identifier DOI: 10.1007/s00345-009-0374-4
Address: http://www.ncbi.nlm.nih.gov/pubmed/19214530
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_19214530.pdf310.26 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.