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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEnalapril Therapy And Cardiac Remodelling In Sickle Cell Disease Patients.pt_BR
dc.contributor.authorLima, Carmen S Ppt_BR
dc.contributor.authorUeti, Osvaldo Mpt_BR
dc.contributor.authorUeti, Adriana Apt_BR
dc.contributor.authorFranchini, Kleber Gpt_BR
dc.contributor.authorCosta, Fernando Fpt_BR
dc.contributor.authorSaad, Sara T Opt_BR
unicamp.authorCarmen S P Lima, Haematology and Haemotherapy Centre, State University of Campinas, Campinas, São Paulo, Brazil. carmenl@fcm.unicamp.brpt_BR
unicamp.author.externalOsvaldo M Ueti,pt
unicamp.author.externalAdriana A Ueti,pt
unicamp.author.externalKleber G Franchini,pt
unicamp.author.externalFernando F Costa,pt
unicamp.author.externalSara T O Saad,pt
dc.subjectAdultpt_BR
dc.subjectAnemia, Sickle Cellpt_BR
dc.subjectAngiotensin-converting Enzyme Inhibitorspt_BR
dc.subjectDiastolept_BR
dc.subjectEchocardiographypt_BR
dc.subjectEnalaprilpt_BR
dc.subjectFemalept_BR
dc.subjectFollow-up Studiespt_BR
dc.subjectHemodynamicspt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectMyocardial Infarctionpt_BR
dc.subjectProspective Studiespt_BR
dc.subjectStroke Volumept_BR
dc.subjectVentricular Remodelingpt_BR
dc.description.abstractAngiotensin-converting enzyme inhibitors (ACEi) have been successfully used for patients with cardiac dysfunction after myocardial infarction. The aim of the present study was to investigate cardiac effects of ACEi in sickle cell disease (SCD) patients, as there are no previous reports regarding these effects. Enalapril was administered to 9 SCD patients with microalbuminuria. Nine SCD patients without microalbuminuria, matched according to age, diagnosis and levels of haemoglobin, haematocrit and foetal haemoglobin did not receive enalapril and were followed up as the control group during the same period of study. Echocardiograms were performed before the study entry and after 36 months of follow-up. At 36 months of follow-up, significant increases in left ventricular mass, left ventricular mass index, posterior left ventricular wall thickness in end-diastole, interventricular septal wall thickness in end-diastole, and aortic root diameter values were seen in untreated, but not in enalapril-treated patients. No major changes were seen in left ventricular systolic diameter, diastolic dimension and ejection fraction, and left atrial diameter, in both groups, along the observational period. The results of this study suggest that enalapril prevents cardiac remodelling in SCD patients. However, a large trial concerning the response to enalapril in patients with SCD should be carried out to further clarify this issue.en
dc.relation.ispartofActa Cardiologicapt_BR
dc.relation.ispartofabbreviationActa Cardiolpt_BR
dc.date.issued2008-Octpt_BR
dc.identifier.citationActa Cardiologica. v. 63, n. 5, p. 599-602, 2008-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume63pt_BR
dc.description.firstpage599-602pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0001-5385pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19014003pt_BR
dc.date.available2015-11-27T13:13:19Z-
dc.date.accessioned2015-11-27T13:13:19Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:13:19Z (GMT). No. of bitstreams: 1 pmed_19014003.pdf: 285931 bytes, checksum: a485447c53448adbd6a4dc38d348541b (MD5) Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198040-
dc.identifier.idPubmed19014003pt_BR
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