Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197622
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA Prospective Study On The Prevalence And Risk Factors For Neonatal Thrombocytopenia And Platelet Alloimmunization Among 9332 Unselected Brazilian Newborns.pt_BR
dc.contributor.authorCastro, Vagnerpt_BR
dc.contributor.authorKroll, Hartmutpt_BR
dc.contributor.authorOriga, Andréa Fpt_BR
dc.contributor.authorFalconi, Mônica Apt_BR
dc.contributor.authorMarques, Sílvia B Dpt_BR
dc.contributor.authorMarba, Sérgio Tpt_BR
dc.contributor.authorPassini, Renatopt_BR
dc.contributor.authorAnnichino-Bizzacchi, Joyce Mpt_BR
dc.contributor.authorCosta, Fernando Fpt_BR
dc.contributor.authorSantoso, Sentotpt_BR
dc.contributor.authorArruda, Valder Rpt_BR
unicamp.authorVagner Castro, Hematology and Transfusion Center, the Department of Neonatology, State University of Campinas, UNICAMP, Campinas-SP, Brazil. vagner@unicamp.brpt_BR
unicamp.author.externalHartmut Kroll,pt
unicamp.author.externalAndréa F Origa,pt
unicamp.author.externalMônica A Falconi,pt
unicamp.author.externalSílvia B D Marques,pt
unicamp.author.externalSérgio T Marba,pt
unicamp.author.externalRenato Passini,pt
unicamp.author.externalJoyce M Annichino-Bizzacchi,pt
unicamp.author.externalFernando F Costa,pt
unicamp.author.externalSentot Santoso,pt
unicamp.author.externalValder R Arruda,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAntibodiespt_BR
dc.subjectAntigens, Human Plateletpt_BR
dc.subjectBlood Plateletspt_BR
dc.subjectBrazilpt_BR
dc.subjectFemalept_BR
dc.subjectGenotypept_BR
dc.subjectHla Antigenspt_BR
dc.subjectHumanspt_BR
dc.subjectInfant, Newbornpt_BR
dc.subjectIsoantibodiespt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectMotherspt_BR
dc.subjectPlatelet Countpt_BR
dc.subjectPrevalencept_BR
dc.subjectProspective Studiespt_BR
dc.subjectRisk Factorspt_BR
dc.subjectThrombocytopeniapt_BR
dc.description.abstractNeonatal thrombocytopenia (NT) occurs in 0.5 to 0.9% of unselected Caucasian newborns. However, the prevalence of this complication in other populations is unknown. In this study the prevalence/causes of NT was determined in Brazilian newborns, a population characterized by admixture among Indigenous, Africans, and Caucasians. A prospective study was carried out in a 3-year period, to determine the prevalence and causes of thrombocytopenia in cord blood samples. Genotyping for HPA 1-5 systems was performed in pairs of mother/neonates with and without thrombocytopenia. All mothers with genotypic mismatches from each group were tested for HPA-specific antibody using the MAIPA technique to identify alloimmunization. Platelet counts <100 x 10(9)/L were detected in 1.5% of 9,332 unselected newborns. In 0.15%, platelet count was <50 x 10(9)/L. Clinically significant bleeding was rare. Underlying diseases were present in 48% of the thrombocytopenic cases. HPA 1-5 system genotype mismatches occurred in 50% of gestations, but did not predict the risk for thrombocytopenia. Notably, mismatched genotypes for HPA-5 were slightly increased in the thrombocytopenic group. The presence of anti-HPA-5b antibodies was observed in 0.05% of unselected pregnancies, but increased to 12% among mothers of neonates with thrombocytopenia and mismatched genotype (N = 51). Neonatal thrombocytopenia is common among Brazilian newborns at rates comparable with those described among Caucasians. These data suggest that screening for genotypic HPA mismatch, followed by an HPA-specific immunoassay system, particularly for the HPA-5 system, among mothers of newborns with thrombocytopenia in our population would allow the identification of pregnancies at risk of alloimmune thrombocytopenia.en
dc.relation.ispartofTransfusionpt_BR
dc.relation.ispartofabbreviationTransfusionpt_BR
dc.date.issued2007-Janpt_BR
dc.identifier.citationTransfusion. v. 47, n. 1, p. 59-66, 2007-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume47pt_BR
dc.description.firstpage59-66pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0041-1132pt_BR
dc.identifier.doi10.1111/j.1537-2995.2007.01064.xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/17207231pt_BR
dc.date.available2015-11-27T13:10:48Z-
dc.date.accessioned2015-11-27T13:10:48Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:10:48Z (GMT). No. of bitstreams: 1 pmed_17207231.pdf: 156213 bytes, checksum: 8317b0f7c324476881beab09c84e67cb (MD5) Previous issue date: 2007en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197622-
dc.identifier.idPubmed17207231pt_BR
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