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dc.typeArtigo de periódicopt_BR
dc.titlePolymorphisms In Methylenetetrahydrofolate Reductase Gene (mthfr) And The Age Of Onset Of Sporadic Colorectal Adenocarcinoma.pt_BR
dc.contributor.authorLima, Carmen S Ppt_BR
dc.contributor.authorNascimento, Helviapt_BR
dc.contributor.authorBonadia, Luciana Cpt_BR
dc.contributor.authorTeori, Maria Tpt_BR
dc.contributor.authorCoy, Claudio S Rpt_BR
dc.contributor.authorGóes, Juvenal R Npt_BR
dc.contributor.authorCosta, Fernando Fpt_BR
dc.contributor.authorBertuzzo, Carmen Spt_BR
unicamp.authorCarmen S P Lima, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, CP: 6111, 13083-970, Brazil. carmenl@fcm.unicamp.brpt_BR Nascimento,pt C Bonadia,pt T Teori,pt S R Coy,pt R N Góes,pt F Costa,pt S Bertuzzo,pt
dc.subjectAge Factorspt_BR
dc.subjectAge Of Onsetpt_BR
dc.subjectColorectal Neoplasmspt_BR
dc.subjectDna, Neoplasmpt_BR
dc.subjectMethylenetetrahydrofolate Reductase (nadph2)pt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectNeoplasm Stagingpt_BR
dc.subjectPolymerase Chain Reactionpt_BR
dc.subjectPolymorphism, Geneticpt_BR
dc.subjectRetrospective Studiespt_BR
dc.subjectRisk Factorspt_BR
dc.subjectTumor Markers, Biologicalpt_BR
dc.description.abstractEvidence is accumulating for a role of folate in the aetiology of colorectal cancer (CRC). The methylenetetrahydrofolate reductase (MTHFR) gene, involved in folate metabolism, is polymorphic in humans. Since it is unknown whether the MTHFR C677T and A1298C polymorphisms alter the risk for CRC, this was the aim of our study. Genomic DNA from 102 sporadic colorectal adenocarcinoma (SCA) patients and 300 controls was analyzed by polymerase chain reaction followed by restriction digestion for the polymorphisms analyses. The frequencies of MTHFR C677T and A1298C genotypes were similar in patients and controls. Similar overall risks for disease were seen in individuals with the distinct MTHFR genotypes. However, an excess of the MTHFR 677TT and 677CT genotypes was seen in patients under 50 years, compared with patients at an older age (19.2 vs 13.1% and 61.6 vs 39.5%, respectively; P = 0.04). The differences were more prominent when the frequency of the 677TT plus 677CT genotype was seen in both group of patients (80.8 vs 52.6%, respectively; P = 0.01), and in younger patients compared to controls (80.8 vs 52.3%, P < 0.01). Individuals with the combined genotype had 3.82-fold (95% confidence interval, 1.41-10.42) increased risk of developing SCA under 50 years, compared with those harboring the wild-type genotype. These results suggest a role for the MTHFR 677TT plus 677CT genotype in increasing SCA diagnosed at a low age in southeastern Brazil, but additional studies with larger sample sizes should be carried out to clarify this issue.en
dc.relation.ispartofInternational Journal Of Colorectal Diseasept_BR
dc.relation.ispartofabbreviationInt J Colorectal Dispt_BR
dc.identifier.citationInternational Journal Of Colorectal Disease. v. 22, n. 7, p. 757-63, 2007-Jul.pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T13:10:22Z (GMT). No. of bitstreams: 1 pmed_17111187.pdf: 174940 bytes, checksum: 746c1cff64da091a00678a48259409ce (MD5) Previous issue date: 2007en
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