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Type: Artigo de periódico
Title: Histometric Evaluation Of The Effect Of Nicotine Administration On Periodontal Breakdown: An In Vivo Study.
Author: Nociti, F H
Nogueira-Filho, G R
Tramontina, V A
Machado, M A
Barros, S P
Sallum, E A
Sallum, A W
Abstract: The present study investigated the effect of nicotine administration on periodontal breakdown resulting from ligature-induced periodontitis in rats. Twenty adult male Wistar rats were used. After anesthesia, a mandibular first molar was randomly assigned to receive a cotton ligature in the sulcular area while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments. of daily intraperitoneal injections: A - saline solution, B -0.37 mg of nicotine kg, C -0.57 mg of nicotine kg and D -0.73 mg of nicotine/kg. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections. Statistical analysis (ANOVA) revealed greater bone loss (p<0.05) in the ligated teeth of animals which received nicotine (groups B/C D) than in the ligated teeth of animals which received saline solution (group A). In addition, a dose-dependent response was observed among the nicotine groups. A negative effect of nicotine was observed in the unligated teeth of the experimental groups (p<0.05). Therefore, daily administration of nicotine enhanced, in a dose-dependent manner, the effects of local factors in producing periodontal breakdown. Furthermore, the nicotine seemed to have a direct deleterious effect on the periodontal tissues.
Subject: Alveolar Bone Loss
Analysis Of Variance
Dose-response Relationship, Drug
Injections, Intraperitoneal
Periodontal Ligament
Random Allocation
Statistics, Nonparametric
Citation: Journal Of Periodontal Research. v. 36, n. 6, p. 361-6, 2001-Dec.
Rights: fechado
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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