Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Absence Of Mutations In The Homeodomain Of The Msx1 Gene In Patients With Hypodontia.
Author: Scarel, R M
Trevilatto, P C
Di Hipólito, O
Camargo, L E
Line, S R
Abstract: Hypodontia, the congenital absence of one or a few permanent teeth, is one of the most frequent alterations of the human dentition. Although hypodontia does not represent a public health problem, it may cause both speech and masticatory dysfunction and esthetic problems. A missense mutation in the homeodomain of MSX1 gene has been associated with hypodontia of second premolars and third molars in humans. However, another study excluded this gene as causative locus for hypodontia of incisors and premolars. To further investigate the role of the MSX1 gene in human hypodontia, we analyzed the homeobox region of the MSX1 gene in 20 individuals with different patterns of familial or isolated hypodontia. The direct sequencing of PCR products did not show any polymorphisms or mutations in the human MSX1 gene. Our results indicate that inactivation of MSX1 gene in humans must have a highly selective effect on dentition, and other genes must be involved in the cause of hypodontia in humans.
Subject: Anodontia
Base Sequence
Dna Primers
Genes, Homeobox
Homeodomain Proteins
Msx1 Transcription Factor
Mutation, Missense
Polymerase Chain Reaction
Transcription Factors
Citation: American Journal Of Medical Genetics. v. 92, n. 5, p. 346-9, 2000-Jun.
Rights: fechado
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_10861665.pdf77.79 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.