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Type: Artigo de periódico
Title: The Effect Of Lead On The Eruption Rates Of Incisor Teeth In Rats.
Author: Gerlach, R F
Toledo, D B
Novaes, P D
Merzel, J
Line, S R
Abstract: The effects of lead on the continuously erupting rat incisors under normo-, hyper- and hypofunctional conditions were investigated. Left lower incisors of 20 rats were rendered unimpeded (hypofunctional) by cutting them out of occlusion every 2 days; the right lower incisors of these rats were considered hyperfunctional. Measurements on normally growing teeth (normofunctional) were carried out in a group of ten rats whose teeth were not cut but only marked every 2 days. On day 7 of the experiment, half of the rats from these two groups were given a single intraperitoneal injection of lead acetate (40 mg/kg), and the other half received sodium acetate (22 mg/kg). Another group of 15 rats was used to obtain blood samples for lead determination 1 h, and 10, 20, and 30 days after lead administration. Animals were killed on day 32. Hypofunctional incisors from lead-treated rats erupted more slowly than control ones (P<0.05). These results show a previously unreported toxic effect of heavy metals.
Subject: Animals
Body Weight
Dental Occlusion
Follow-up Studies
Injections, Intraperitoneal
Organometallic Compounds
Periodontal Ligament
Random Allocation
Rats, Wistar
Sodium Acetate
Statistics As Topic
Tooth Eruption
Citation: Archives Of Oral Biology. v. 45, n. 11, p. 951-5, 2000-Nov.
Rights: fechado
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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