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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleBasement Membrane Associated Changes In The Rat Ventral Prostate Following Castration.pt_BR
dc.contributor.authorde Carvalho, H Fpt_BR
dc.contributor.authorLine, S Rpt_BR
unicamp.authorH F de Carvalho, Department of Cell Biology-IB-UNICAMP, Campinas SP, Brazil.pt_BR
unicamp.author.externalS R Line,pt
dc.subjectAndrogenspt_BR
dc.subjectAnimalspt_BR
dc.subjectBasement Membranept_BR
dc.subjectCollagenpt_BR
dc.subjectGlycosaminoglycanspt_BR
dc.subjectLamininpt_BR
dc.subjectMalept_BR
dc.subjectOrchiectomypt_BR
dc.subjectProstatept_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.description.abstractThis study focuses on the basement membrane associated modifications that take place after androgen blockade, by studying some of its main components, through histochemical, immuno-histochemical and Western blotting tests, and its ultrastructural aspects. It was demonstrated that laminin and collagen type IV remain associated with a thickened basement membrane and that there is an apparent increase in heparan sulfate content 21 days after castration. Ultrastructurally, basal lamina appeared extensively folded and pleated. It was also observed that detachment of epithelial cells is not dependent of basal lamina degradation and that the free basal lamina surfaces are folded by the action of adjacent cells. We have also observed some aspects of smooth muscle cell degeneration and death, that lead to modifications of the associated basal lamina. In this case, residual basal lamina also shows extensive folding. The results suggested that degradation of excess basement membrane does not occur or is a very slow process within the period examined, and that basement membrane is left re-organized but ultrastructurally and compositionally unaffected.en
dc.relation.ispartofCell Biology Internationalpt_BR
dc.relation.ispartofabbreviationCell Biol. Int.pt_BR
dc.date.issued1996-Decpt_BR
dc.identifier.citationCell Biology International. v. 20, n. 12, p. 809-19, 1996-Dec.pt_BR
dc.language.isoengpt_BR
dc.description.volume20pt_BR
dc.description.firstpage809-19pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1065-6995pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/9032941pt_BR
dc.date.available2015-11-27T12:18:50Z-
dc.date.accessioned2015-11-27T12:18:50Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:18:50Z (GMT). No. of bitstreams: 1 pmed_9032941.pdf: 2890204 bytes, checksum: 8d03f6699f80bb130897bf5805c98331 (MD5) Previous issue date: 1996en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193975-
dc.identifier.idPubmed9032941pt_BR
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