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Sb225002 induces cell death and cell cycle arrest in Acute Lymphoblastic leukemia cells through the activation of glipr1

Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea). Although initially described as a selective antagonist of CXCR2, later studies have identif...

Genomic variants revealed by invariably missing genotypes in nelore cattle

High density genotyping panels have been used in a wide range of applications. From population genetics to genome-wide association studies, this technology still offers the lowest cost and the most consistent solution for generating SNP data. However, in spite of the application, part&#...

De novo transcriptome assembly and analysis to identify potential gene targets for RNAi-mediated control of the tomato Leafminer (tuta Absoluta)

Providing double-stranded RNA (dsRNA) to insects has been proven to silence target genes, and this approach has emerged as a potential method to control agricultural pests by engineering plants to express insect dsRNAs. A critical step of this technology is the screening of effecti...

Combined liver x receptor/peroxisome proliferator-activated receptor agonist treatment reduces amyloid levels and improves behavior in amyloid precursor protein/presenilin 1 mice

In the brain, the type II nuclear receptors LXR and PPAR control cholesterol efflux and inflammation, key processes in Alzheimer disease pathology. Results: Combining the LXR and PPAR agonists decreases the levels of A and inflammation, resulting in improved cognition. Conclusion: The L...

Association of nitric oxide synthase and matrix metalloprotease single nucleotide polymorphisms with preeclampsia and its complications

Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality in the world, but its appearance is still unpredictable and its pathophysiology has not been entirely elucidated. Genetic studies have associated single nucleotide polymorphisms in genes encoding nitri...

In-vivo evaluation of the surface roughness and morphology of enamel after bracket removal and polishing by different techniques

Sem informação

A estrutura latente da depressão em idosos: uma análise taxométrica

O objetivo deste estudo foi investigar a estrutura latente da depressão em uma amostra não clínica de idosos, utilizando a análise taxométrica. Essa análise é uma família de procedimentos estatísticos concebidos para testar se um determinado construto é mais bem representado por categor...


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Sistema de Bibliotecas da Unicamp - SBU
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